Alberto Mantovani, Scientific Director of 麻豆传媒AV在线看 and Professor at 麻豆传媒AV在线看 University, has received the Milstein Award, the most important international award for听research听on cytokines and听interferon. The Awards have been presented at听the annual meeting of the听International Cytokine & Interferon Society (ICIS) on October 11th.
What are cytokines?
Cytokines are small proteins generated by different types of cells and able to bind听specific receptors on the cell membrane and to give cells specific instructions as the stimulus of听growing, differentiating or dying. Immune-generated cytokines, as 颈苍迟别谤濒别耻办颈苍别蝉听补苍诲听肠丑别尘辞办颈苍别蝉, play a key role in the regulation and activation of our defenses and in inflammation.
Prof Mantovani has contributed to establish the function of interleukine-6 (IL-6) during the transition from acute to chronic inflammation. Mantovani and his team have also identified and explained how IL-1听decoy听receptor听works: the receptor binds听the protein without allowing the signal emission and so inhibiting its action. This has had important clinical consequences: today it is in fact possible to stop inflammatory cytokines by converting听their receptors into decoy receptors.
Alberto Mantovani‘s research has always been focused on immune defense mechanisms, especially the most primitives (innate immunity). In the late 鈥�70s his studies demonstrated the protumor function of tumor-associated macrophages, thus proving the existence of a inflammation-cancer connection.
Prof. Mantovani also discovered PTX3,听a paradigm for humoral innate immunity which acts as an extrinsic oncosuppressor regulating complement and macrophage driven tumor promoting inflammation. Clinical trials have already been activated.
About the Milstein Award
The for Excellence in Interferon and Cytokine Research was听established in 1988, two years after interferon was first approved for the treatment of hairy cell leukemia by Philip, Vivian e Connie Milstein, a family of philanthropists internationally听known for its听support to the research听on cytokines and听interferon.
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