{"id":36945,"date":"2015-11-06T00:00:00","date_gmt":"2015-11-06T00:00:00","guid":{"rendered":"https:\/\/www.hunimed.eu\/news\/il-prof-mantovani-riceve-il-premio-milstein\/"},"modified":"2025-10-14T02:36:45","modified_gmt":"2025-10-14T02:36:45","slug":"il-prof-mantovani-riceve-il-premio-milstein","status":"publish","type":"post","link":"https:\/\/www.hunimed.eu\/it\/news\/il-prof-mantovani-riceve-il-premio-milstein\/","title":{"rendered":"Il prof. Mantovani riceve il premio Milstein"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-22209 size-medium\" src=\"https:\/\/www.hunimed.eu\/wp-content\/uploads\/2015\/11\/mantovani1-e1447001022956-300x167.jpg\" alt=\"mantovani1\" width=\"300\" height=\"167\" \/><strong><a href=\"http:\/\/www.humanitas-research.org\/mantovani-alberto\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Alberto Mantovani<\/a><\/strong>, Direttore Scientifico di 麻豆传媒AV在线看 e Professore di 麻豆传媒AV在线看 University, ha ricevuto il prestigioso <strong>premio Milstein<\/strong>, il pi\u00f9 importante riconoscimento internazionale nel campo della <strong>ricerca sulle citochine e sugli interferoni<\/strong>, proteine da cui dipende il coordinamento fisiologico del sistema immunitario.\u00a0<br \/>Le premiazioni si sono tenute lo scorso 11 ottobre durante il meeting annuale dell\u2019International Cytokine &amp; Interferon Society (ICIS).<\/p>\n<h2>Cosa sono le citochine?<\/h2>\n<p>Le\u00a0<strong>citochine<\/strong>\u00a0sono piccole\u00a0<strong>proteine<\/strong> prodotte da diversi tipi di cellule e capaci di legarsi a specifici recettori presenti sulla membrana cellulare e <strong>comunicare<\/strong>\u00a0<strong>alla cellula un\u2019istruzione specifica<\/strong> come lo stimolo a crescere, a differenziarsi o\u00a0a\u00a0morire. In particolare le citochine prodotte dalle cellule del\u00a0sistema immunitario, come le\u00a0<strong>interleuchine<\/strong>\u00a0e le\u00a0<strong>chemochine<\/strong>, svolgono un ruolo fondamentale nella regolazione e nell\u2019attivazione dei nostri <strong>meccanismi difensivi<\/strong> e nei <strong>processi infiammatori<\/strong>.<\/p>\n<h2>Le scoperte del Prof. Mantovani<\/h2>\n<p>Il prof. Mantovani ha contribuito a stabilire la funzione dell\u2019<strong>interleuchina-6<\/strong> nella transizione dalla fase acuta a quella cronica dell\u2019infiammazione. Mantovani e il suo team hanno anche identificato e spiegato il meccanismo di funzionamento del <strong>recettore decoy<\/strong> (\u2018<strong>trappola molecolare<\/strong>\u2019) per l\u2019interleuchina-1:\u00a0Il\u00a0recettore si lega alla proteina-messaggero senza per\u00f2\u00a0tradurne il segnale e inibendone cos\u00ec l\u2019azione. Questa scoperta ha avuto importanti implicazioni dal punto di vista clinico: oggi, infatti, modificando i recettori e trasformandoli in decoy, \u00e8 possibile\u00a0<strong>bloccare l\u2019azione di citochine che scatenano l\u2019infiammazione<\/strong>.<\/p>\n<p>Focus della ricerca del prof. Alberto Mantovani sono, da sempre, i meccanismi di <strong>difesa immunologica<\/strong>, soprattutto i\u00a0sistemi pi\u00f9 primitivi (immunit\u00e0 innata). In particolare, i suoi studi iniziati negli anni \u201870 hanno svelato come i <strong>macrofagi<\/strong>\u00a0presenti all\u2019interno dei tumori si comportino come \u201cpoliziotti corrotti\u201d contribuendo alla crescita e alla progressione neoplastica.<\/p>\n<p>Al prof. Mantovani si deve anche la scoperta di <strong><a href=\"http:\/\/www.humanitas.it\/news\/8950-ptx3-il-gene-che-spegne-il-cancro\" target=\"_blank\" rel=\"noopener noreferrer\">PTX3<\/a>,\u00a0<\/strong>molecola dell\u2019immunit\u00e0 innata\u00a0con\u00a0ruolo oncosoppressore, caratterizzata da un\u00a0meccanismo di azione nuovo e unico. \u00a0\u00c8 gi\u00e0 stata attivata la sperimentazione clinica per portare la molecola dal laboratorio al letto del paziente.<\/p>\n<h2>Che cos\u2019\u00e8 il premio Milstein?<\/h2>\n<p>Il premio fu istituito nel 1988 \u2013 due anni esatti dopo l\u2019approvazione dell\u2019interferone nel trattamento della leucemia a cellule capellute \u2013 da Philip, Vivian e Connie Milstein, una famiglia di filantropi molto conosciuta negli Stati Uniti e nel resto del mondo per il <strong>sostegno alla ricerca sulle citochine e gli interferoni<\/strong>. Il premio \u00e8 attribuito annualmente a scienziati che si siano particolarmente distinti nella ricerca di base e clinica in questo campo.<\/p>\n<p>Per saperne di pi\u00f9, visitate il sito del <strong><a href=\"http:\/\/www.milstein-award.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">premio Milstein<\/a><\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alberto Mantovani, Direttore Scientifico di 麻豆传媒AV在线看 e Professore di 麻豆传媒AV在线看 University, ha ricevuto il prestigioso premio Milstein, il pi\u00f9 importante riconoscimento internazionale nel campo della ricerca sulle citochine e sugli interferoni, proteine da cui dipende il coordinamento fisiologico del sistema immunitario.\u00a0Le premiazioni si sono tenute lo scorso 11 ottobre durante il meeting annuale dell\u2019International Cytokine [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14290,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","footnotes":""},"categories":[401,2025,2385],"tags":[414,1645,2405],"class_list":["post-36945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mondo-humanitas","category-scienze-mediche-3-2","category-tutti-5","tag-alberto-mantovani","tag-humanitas-2","tag-ricerca-5"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Il prof. 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