{"id":11532,"date":"2020-01-08T10:16:40","date_gmt":"2020-01-08T10:16:40","guid":{"rendered":"http:\/\/hunimed-new.local\/Member\/letterio-salvatore-politi-2\/"},"modified":"2026-03-31T15:06:43","modified_gmt":"2026-03-31T15:06:43","slug":"letterio-salvatore-politi","status":"publish","type":"member","link":"https:\/\/www.hunimed.eu\/it\/member\/letterio-salvatore-politi\/","title":{"rendered":"Letterio Salvatore Politi"},"content":{"rendered":"\n<div class=\"wp-block-hunimed-tabs-content hunimed-tabs-content-block\"><div class=\"tabs-container\">\n<div class=\"wp-block-hunimed-tabs-content-tab tabs-content-tab\"><div class=\"tab-item\" data-tab-title=\"Biosketch\"><div class=\"tab-header\"><button class=\"tab-nav\" role=\"tab\" aria-selected=\"false\"><span class=\"tab-title\">Biosketch<\/span><\/button><\/div><div class=\"tab-content\" role=\"tabpanel\" aria-hidden=\"true\">\n<p class=\"wp-block-paragraph\">Sono un medico scienziato e un neuroradiologo clinico con 20 anni di esperienza. La mia ricerca si concentra principalmente sul settore del&nbsp;Neuroimaging e la&nbsp;risonanza magnetica avanzata (RM), e in particolare sulla quantificazione non invasiva del carico di malattia attraverso la RM, con l&#8217;obiettivo di definire la storia naturale della malattia e le misure di esito nella neuroimmagine traslazionale e clinica. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ho una lunga esperienza nella risonanza magnetica quantitativa del cervello e del midollo spinale, con competenze specifiche nella quantificazione del carico delle lesioni, nelle analisi volumetriche e nella quantificazione del danno microstrutturale attraverso l&#8217;analisi dei tensori di diffusione, nell&#8217;impostazione di diverse malattie neurologiche. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In qualit\u00e0 di Direttore della Ricerca di Neuroimaging all&#8217;Ospedale Pediatrico di Boston e come Direttore degli Affari Clinici dell&#8217;Advanced MR Imaging Center (AMRIC), struttura di core imaging dell&#8217;UMASS, sto promuovendo la ricerca di MR imaging clinico (MRI), mettendo a disposizione la mia esperienza nelle tecniche avanzate di MRI e nella validazione di misure di esito basate sulla MRR negli studi clinici. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sono autore di 67 articoli scientifici (fattore di impatto totale: 458.282; indice h: 26; citazioni totali: oltre 3.300 &#8211; Scopus) nel campo della neuroimaging con particolare attenzione alle tecniche avanzate di RM, all&#8217;imaging con cellule staminali, ai tumori cerebrali, alle malattie vascolari, ai disturbi neuromuscolari e ai disturbi neurodegenerativi ereditari. Ho collaborato alla validazione di nuovi radiotracciatori PET e allo sviluppo di un apparato integrato di imaging multimodale SPECT\/MRI. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ho eseguito la revisione radiologica centrale per diversi studi internazionali multicentrici su disturbi cerebrali, orbitali e neuromuscolari.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-hunimed-tabs-content-tab tabs-content-tab\"><div class=\"tab-item\" data-tab-title=\"Ricerca\"><div class=\"tab-header\"><button class=\"tab-nav\" role=\"tab\" aria-selected=\"false\"><span class=\"tab-title\">Ricerca<\/span><\/button><\/div><div class=\"tab-content\" role=\"tabpanel\" aria-hidden=\"true\">\n<ul class=\"wp-block-list\">\n<li><strong>AIRC 2014 03\/01\/2015 \u2013 03\/31\/2019<\/strong> Prognostic value of 18F-FAZA PET\/CT in high grade glioma: comparison with MRI and correlation with hypoxia biomarkers Main Goals: assessment of accuracy of PET and perfusion\/permeability MRI in detecting hypoxia within high grade brain tumors. Role: Co-Investigator <\/li>\n\n\n\n<li><strong>2017 &#8211; 2019<\/strong>: <strong>US Army Medical Research Acquisition Activity:<\/strong> Microglia-Targeted MRI\/PET Traceable Nanovectors: Theranostic Platform for Tracking and Shaping Microglia Reactivity to Improve ALS Therapy. Main goals: To validate the therapeutic potential of nanoparticles targeted to activated microglia and optimized for controlled release of small molecules or oligonucleotydes in rodent models of amyotrophic lateral sclerosis. Role: Co-investigator<strong>&nbsp;<\/strong>Completed support: European Union FP7&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <\/li>\n\n\n\n<li><strong>2013 &#8211; 2017:<\/strong> INSERT (INtegrated SPECT-MRI for Enhanced stratification of Radio-chemio Therapy) Main Goals: development and preclinical and clinical validation of an integrated SPECT-MRI system Role: P.I. of Unit<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-hunimed-tabs-content-tab tabs-content-tab\"><div class=\"tab-item\" data-tab-title=\"Pubblicazioni\"><div class=\"tab-header\"><button class=\"tab-nav\" role=\"tab\" aria-selected=\"false\"><span class=\"tab-title\">Pubblicazioni<\/span><\/button><\/div><div class=\"tab-content\" role=\"tabpanel\" aria-hidden=\"true\">\n<ol class=\"wp-block-list\">\n<li><strong>Politi LS<\/strong>, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, Comi G, Scotti G, Martino G, Pluchino S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17600110\/\">Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis<\/a>. Stem Cells. 2007; 25(10):2583-92.<\/li>\n\n\n\n<li>Luchetti A, Milani D, Ruffini F, Galli R, Falini A, Quattrini A, Scotti G, Comi G, Martino G, Furlan R, <strong>Politi LS<\/strong>. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22469239\/\">Monoclonal antibodies conjugated with superparamagnetic iron oxide particles allow magnetic resonance imaging detection of lymphocytes in the mouse brain<\/a>. Mol Imaging. 2012; 11(2):114-25.<\/li>\n\n\n\n<li>Cianciaruso C, Pagani A, Martelli C, Bacigaluppi M, Squadrito ML, Lo Dico A, De Palma M, Furlan R, Lucignani G, Falini A, Biffi A, Ottobrini L, <strong>Politi LS<\/strong>. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24823433\/\">Cellular magnetic resonance with iron oxide nanoparticles: long-term persistence of SPIO signal in the CNS after transplanted cell death<\/a>. Nanomedicine. 2014; 9(10):1457-74.<\/li>\n\n\n\n<li>Mazzoleni S, <strong>Politi LS<\/strong>, Pala M, Cominelli M, Franzin A, Sergi Sergi L, Falini A, De Palma M, Bulfone A, Poliani PL, Galli R. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20858720\/\">Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis<\/a>. Cancer Res. 2010; 70(19):7500-13.<\/li>\n\n\n\n<li>Visigalli I, Delai S, <strong>Politi LS<\/strong>, Di Domenico C, Cerri F, Mrak E, D&#8217;Isa R, Ungaro D, Stok M, Sanvito F, Mariani E, Staszewsky L, Godi C, Russo I, Cecere F, Del Carro U, Rubinacci A, Brambilla R, Quattrini A, Di Natale P, Ponder K, Naldini L, Biffi A. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20847202\/\">Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model<\/a>. Blood. 2010; 116(24):5130-9. PMCID: PMC3709639.<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":49081,"template":"","departaments":[147,270],"roles":[203,206],"class_list":["post-11532","member","type-member","status-publish","has-post-thumbnail","hentry","departament-neuroradiologia","departament-neuroradiologia-2","role-full-professor-it","role-professore-ordinario"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Letterio Salvatore Politi - Hunimed<\/title>\n<meta name=\"description\" content=\"Biosketch Sono un medico scienziato e un neuroradiologo clinico con 20 anni di esperienza. 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